Last updated on September 2018

Ipilimumab and Nivolumab in Leptomeningeal Metastases


Brief description of study

This research study is studying a combination of two drugs as a possible treatment for Leptomeningeal Metastases.

The names of the study interventions involved in this study are:

  • Ipilimumab
  • Nivolumab

Detailed Study Description

This research study is a Phase II clinical trial.

Researchers hope to study the effects of the combination of Nivolumab and Ipilimumab. Many cancers use specific pathways (such as PD-1/PD-L1 and CTLA-4) to evade the body's immune system. Nivolumab and ipilimumab work by blocking the PD-1/PD-L1 and CTLA-4 pathways and thus releasing the brakes on the immune system so it can stop or slow cancer.

The FDA (the U.S. Food and Drug Administration) has approved Nivolumab and Ipilimumab as a treatment option for melanoma, but has not approved them for use when cancer cells spread to the cerebrospinal fluid

Clinical Study Identifier: NCT02939300

Contact Investigators or Research Sites near you

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Priscilla Brastianos, MD

Massachusetts general Hospital
Boston, MA United States
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Eudocia K Quant Lee, MD ...

Dana Farber Cancer Institute
Boston, MA United States
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