Last updated on December 2018

Registrational Study With Omecamtiv Mecarbil/AMG 423 to Treat Chronic Heart Failure With Reduced Ejection Fraction


Brief description of study

The purpose of this study is to determine if treatment with omecamtiv mecarbil/AMG 423 when added to standard of care is well tolerated and superior to placebo in reducing the risk of cardiovascular death or heart failure events in subjects with chronic HFrEF.

Clinical Study Identifier: NCT02929329

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Amgen Call Center

Research Site
Osaka-shi, Japan
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Amgen Call Center

Research Site
Ureshino-machi, Japan
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Amgen Call Center

Research Site
Koshigaya-shi, Japan
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Amgen Call Center

Research Site
Wako-shi, Japan
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Amgen Call Center

Research Site
Akishima-shi, Japan
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Amgen Call Center

Research Site
Chuo-ku, Japan
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Amgen Call Center

Research Site
Toyama-shi, Japan
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Amgen Call Center

Research Site
Kaunas, Lithuania
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Amgen Call Center

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Vilnius, Lithuania
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Amgen Call Center

Research Site
Mexico, Mexico
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Amgen Call Center

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Aguascalientes, Mexico
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Amgen Call Center

Research Site
's Hertogenbosch, Netherlands
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Almelo, Netherlands
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Breda, Netherlands
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Amgen Call Center

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Capelle aan de IJssel, Netherlands
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Den Helder, Netherlands
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Deventer, Netherlands
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Amgen Call Center

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Doetinchem, Netherlands
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Amgen Call Center

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Emmen, Netherlands
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Amgen Call Center

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Goes, Netherlands
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Amgen Call Center

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Groningen, Netherlands
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Amgen Call Center

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Leiderdorp, Netherlands
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Amgen Call Center

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Nijmegen, Netherlands
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Amgen Call Center

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Tiel, Netherlands
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Amgen Call Center

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Uden, Netherlands
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Amgen Call Center

Research Site
Christchurch, New Zealand
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Amgen Call Center

Research Site
Papatoetoe, Auckland, New Zealand
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Amgen Call Center

Research Site
Takapuna, Auckland, New Zealand
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Amgen Call Center

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Gdansk, Poland
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Amgen Call Center

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Gdynia, Poland
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Amgen Call Center

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Gizycko, Poland
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Amgen Call Center

Research Site
Krakow, Poland
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Amgen Call Center

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Lodz, Poland
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Amgen Call Center

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Lublin, Poland
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Amgen Call Center

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Miechow, Poland
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Amgen Call Center

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Piotrkow Trybunalski, Poland
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Amgen Call Center

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Ruda Slaska, Poland
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Amgen Call Center

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Skierniewice, Poland
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Amgen Call Center

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Stalowa Wola, Poland
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Amgen Call Center

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Swidnik, Poland
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Amgen Call Center

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Tarnow, Poland
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Amgen Call Center

Research Site
Torun, Poland
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Amgen Call Center

Research Site
Warszawa, Poland
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Amgen Call Center

Research Site
Wloclawek, Poland
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Amgen Call Center

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Zabrze, Poland
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Amgen Call Center

Research Site
Aveiro, Portugal
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Amgen Call Center

Research Site
Coimbra, Portugal
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Amgen Call Center

Research Site
Covilha, Portugal
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Amgen Call Center

Research Site
Guimaraes, Portugal
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Amgen Call Center

Research Site
Lisboa, Portugal
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Amgen Call Center

Research Site
Setubal, Portugal
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Amgen Call Center

Research Site
San Juan, Puerto Rico
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Amgen Call Center

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Bucharest, Romania
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Amgen Call Center

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Bucuresti, Romania
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Amgen Call Center

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Cluj-Napoca, Romania
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Craiova, Romania
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Amgen Call Center

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Iasi, Romania
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Pitesti, Romania
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Amgen Call Center

Research Site
Barnaul, Russian Federation
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Ekaterinburg, Russian Federation
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Ivanovo, Russian Federation
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Amgen Call Center

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Izhevsk, Russian Federation
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Amgen Call Center

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Kemerovo, Russian Federation
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Amgen Call Center

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Kirov, Russian Federation
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Amgen Call Center

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Korolev, Russian Federation
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Amgen Call Center

Research Site
Krasnodar, Russian Federation
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Amgen Call Center

Research Site
Lomonosov, Russian Federation
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Amgen Call Center

Research Site
Moscow, Russian Federation
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Amgen Call Center

Research Site
Nizhniy Novgorod, Russian Federation
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Amgen Call Center

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Nizhny Novgorod, Russian Federation
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Novosibirsk, Russian Federation
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Omsk, Russian Federation
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Saint Petersburg, Russian Federation
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Amgen Call Center

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Saint-Petersburg, Russian Federation
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Saratov, Russian Federation
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Amgen Call Center

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St. Petersburg, Russian Federation
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Amgen Call Center

Research Site
Tomsk, Russian Federation
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Amgen Call Center

Research Site
village Novoseltsy, Russian Federation
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Amgen Call Center

Research Site
Banska Bystrica, Slovakia
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Amgen Call Center

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Bardejov, Slovakia
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Amgen Call Center

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Bratislava, Slovakia
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Amgen Call Center

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Brezno, Slovakia
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Amgen Call Center

Research Site
Kosice, Slovakia
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Amgen Call Center

Research Site
Rimavska Sobota, Slovakia
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Amgen Call Center

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Snina, Slovakia
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Amgen Call Center

Research Site
Svidnik, Slovakia
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Amgen Call Center

Research Site
Parow, South Africa
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Amgen Call Center

Research Site
Cordoba, Spain
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Amgen Call Center

Research Site
Malaga, Spain
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Amgen Call Center

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Sevilla, Spain
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Amgen Call Center

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Ubeda, Spain
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Amgen Call Center

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Oviedo, Spain
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Amgen Call Center

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Santander, Spain
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Amgen Call Center

Research Site
Barcelona, Spain
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Amgen Call Center

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Alicante, Spain
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Amgen Call Center

Research Site
Valencia, Spain
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Amgen Call Center

Research Site
Santiago de Compostela, Spain
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Amgen Call Center

Research Site
Vigo, Spain
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Amgen Call Center

Research Site
Majadahonda, Spain
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Amgen Call Center

Research Site
El Palmar, Spain
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Amgen Call Center

Research Site
Madrid, Spain
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Amgen Call Center

Research Site
Falun, Sweden
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Amgen Call Center

Research Site
Jonkoping, Sweden
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Amgen Call Center

Research Site
Linkoping, Sweden
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Amgen Call Center

Research Site
Lund, Sweden
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Amgen Call Center

Research Site
Orebro, Sweden
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Amgen Call Center

Research Site
Skelleftea, Sweden
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Amgen Call Center

Research Site
Basel, Switzerland
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Amgen Call Center

Research Site
Bern, Switzerland
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Amgen Call Center

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Fribourg, Switzerland
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Amgen Call Center

Research Site
Lausanne, Switzerland
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Amgen Call Center

Research Site
Lugano, Switzerland
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Amgen Call Center

Research Site
Zurich, Switzerland
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Amgen Call Center

Research Site
Adana, Turkey
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Amgen Call Center

Research Site
Afyonkarahisar, Turkey
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Amgen Call Center

Research Site
Ankara, Turkey
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Amgen Call Center

Research Site
Corum, Turkey
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Amgen Call Center

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Eskisehir, Turkey
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Amgen Call Center

Research Site
Istanbul, Turkey
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Amgen Call Center

Research Site
Izmir, Turkey
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Amgen Call Center

Research Site
Kirikkale, Turkey
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Amgen Call Center

Research Site
Kocaeli, Turkey
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Amgen Call Center

Research Site
Konya, Turkey
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Amgen Call Center

Research Site
Mersin, Turkey
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Amgen Call Center

Research Site
Sakarya, Turkey
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Amgen Call Center

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Sivas, Turkey
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Amgen Call Center

Research Site
Van, Turkey
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Amgen Call Center

Research Site
Dnipropetrovsk, Ukraine
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Amgen Call Center

Research Site
Ivano-Frankivsk, Ukraine
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Amgen Call Center

Research Site
Kharkiv, Ukraine
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Amgen Call Center

Research Site
Kyiv, Ukraine
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Amgen Call Center

Research Site
Lutsk, Ukraine
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Amgen Call Center

Research Site
Uzhgorod, Ukraine
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Amgen Call Center

Research Site
Vinnytsia, Ukraine
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Amgen Call Center

Research Site
Vinnytsya, Ukraine
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Amgen Call Center

Research Site
Zaporizhzhia, Ukraine
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Amgen Call Center

Research Site
Zaporizhzhya, Ukraine
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Amgen Call Center

Research Site
Ayr, United Kingdom
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Amgen Call Center

Research Site
Basingstoke, United Kingdom
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Amgen Call Center

Research Site
Belfast, United Kingdom
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Amgen Call Center

Research Site
Cottingham, United Kingdom
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Amgen Call Center

Research Site
Dudley, United Kingdom
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Amgen Call Center

Research Site
Dundee, United Kingdom
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Amgen Call Center

Research Site
Exeter, United Kingdom
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Amgen Call Center

Research Site
Gillingham, United Kingdom
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Amgen Call Center

Research Site
Glasgow, United Kingdom
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Amgen Call Center

Research Site
Harlow, United Kingdom
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Amgen Call Center

Research Site
High Wycombe, United Kingdom
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Amgen Call Center

Research Site
Merthyr Tydfil, United Kingdom
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Amgen Call Center

Research Site
Newport, United Kingdom
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Amgen Call Center

Research Site
Northampton, United Kingdom
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Amgen Call Center

Research Site
Norwich, United Kingdom
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Amgen Call Center

Research Site
Portsmouth, United Kingdom
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Amgen Call Center

Research Site
Solihull, United Kingdom
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Amgen Call Center

Research Site
Stevenage, United Kingdom
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Amgen Call Center

Research Site
Sunderland, United Kingdom
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Amgen Call Center

Research Site
Swindon, United Kingdom
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Amgen Call Center

Research Site
Taunton, United Kingdom
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Amgen Call Center

Research Site
Torquay, United Kingdom
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Amgen Call Center

Research Site
Worcester, United Kingdom
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Amgen Call Center

Research Site
Tucson, AZ United States
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Amgen Call Center

Research Site
Stanford, CA United States
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Amgen Call Center

Research Site
Hartford, CT United States
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Amgen Call Center

Research Site
Washington, WA United States
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Amgen Call Center

Research Site
Honolulu, HI United States
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Amgen Call Center

Research Site
Merrillville, IN United States
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Amgen Call Center

Research Site
Iowa City, IA United States
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Amgen Call Center

Research Site
Kansas City, KS United States
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Amgen Call Center

Research Site
Springfield, MO United States
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Amgen Call Center

Research Site
Reno, NV United States
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Amgen Call Center

Research Site
Bronx, NY United States
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Amgen Call Center

Research Site
Cortlandt Manor, NY United States
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Amgen Call Center

Research Site
Roslyn, NY United States
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Amgen Call Center

Research Site
Valhalla, NY United States
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Amgen Call Center

Research Site
Winston-Salem, NC United States
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Amgen Call Center

Research Site
Lynchburg, VA United States
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Amgen Call Center

Research Site
Waukesha, WI United States
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Amgen Call Center

Research Site
Bahia Blanca, Argentina
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Amgen Call Center

Research Site
Aalst, Belgium
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Amgen Call Center

Research Site
Brasilia, Brazil
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Amgen Call Center

Research Site
Goiania, Brazil
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Amgen Call Center

Research Site
Belo Horizonte, Brazil
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Amgen Call Center

Research Site
Curitiba, Brazil
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Amgen Call Center

Research Site
Natal, Brazil
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Amgen Call Center

Research Site
Passo Fundo, Brazil
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Amgen Call Center

Research Site
Porto Alegre, Brazil
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Amgen Call Center

Research Site
Campinas, Brazil
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Amgen Call Center

Research Site
Sao Jose do Rio Preto, Brazil
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Amgen Call Center

Research Site
Rio De Janeiro, Brazil
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Amgen Call Center

Research Site
Medellin, Colombia
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Amgen Call Center

Research Site
Barranquilla, Colombia
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Amgen Call Center

Research Site
Cartagena, Colombia
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Amgen Call Center

Research Site
Manizales, Colombia
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Amgen Call Center

Research Site
Armenia, Colombia
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Amgen Call Center

Research Site
Bucaramanga, Colombia
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Amgen Call Center

Research Site
Frydek Mistek, Czechia
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Amgen Call Center

Research Site
Marianske Lazne, Czechia
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Amgen Call Center

Research Site
Nantes Cedex 2, France
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Amgen Call Center

Research Site
Toulon Cedex, France
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Amgen Call Center

Research Site
Tourcoing cedex, France
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Amgen Call Center

Research Site
Cegled, Hungary
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Amgen Call Center

Research Site
Kaposvar, Hungary
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Amgen Call Center

Research Site
Pavia, Italy
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Amgen Call Center

Research Site
Torrette Di Ancona, Italy
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Amgen Call Center

Research Site
Funabashi-shi, Japan
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Amgen Call Center

Research Site
Kahoku-gun, Japan
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Amgen Call Center

Research Site
Kanazawa-shi, Japan
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Amgen Call Center

Research Site
Takamatsu-shi, Japan
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Amgen Call Center

Research Site
Nagano-shi, Japan
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Amgen Call Center

Research Site
Shimajiri-gun, Japan
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Amgen Call Center

Research Site
Higashiosaka-shi, Japan
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Amgen Call Center

Research Site
Suita-shi, Japan
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Amgen Call Center

Research Site
Kusatsu-shi, Japan
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Amgen Call Center

Research Site
Fussa-shi, Japan
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Amgen Call Center

Research Site
Itabashi-ku, Japan
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Amgen Call Center

Research Site
Kodaira-shi, Japan
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Amgen Call Center

Research Site
Meguro-ku, Japan
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Amgen Call Center

Research Site
Klaipeda, Lithuania
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Amgen Call Center

Research Site
Torreon, Mexico
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Amgen Call Center

Research Site
Zapopan, Mexico
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Amgen Call Center

Research Site
Monterrey, Mexico
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Amgen Call Center

Research Site
Capelle Aan De IJssel, Netherlands
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Amgen Call Center

Research Site
Timisoara, Romania
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Amgen Call Center

Research Site
Arkhangelsk, Russian Federation
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Amgen Call Center

Research Site
Village Novoseltsy, Russian Federation
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Amgen Call Center

Research Site
Bloemfontein, South Africa
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Amgen Call Center

Research Site
Sunninghill, South Africa
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Amgen Call Center

Research Site
Durban, South Africa
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Amgen Call Center

Research Site
Umhlanga, South Africa
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Amgen Call Center

Research Site
Somerset West, South Africa
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Amgen Call Center

Research Site
Granada, Spain
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Amgen Call Center

Research Site
Valladolid, Spain
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Amgen Call Center

Research Site
Birmingham, AL United States
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Amgen Call Center

Research Site
San Francisco, CA United States
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Amgen Call Center

Research Site
Colorado Springs, CO United States
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Amgen Call Center

Research Site
Altamonte Springs, FL United States
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Amgen Call Center

Research Site
Palm Harbor, FL United States
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Amgen Call Center

Research Site
Arlington Heights, IL United States
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Amgen Call Center

Research Site
Bangor, ME United States
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Amgen Call Center

Research Site
Hagerstown, MD United States
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Amgen Call Center

Research Site
Johnson City, NY United States
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Amgen Call Center

Research Site
Saratoga Springs, NY United States
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Amgen Call Center

Research Site
Pinehurst, NC United States
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Amgen Call Center

Research Site
Wiloughby, OH United States
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Amgen Call Center

Research Site
Abington, PA United States
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Amgen Call Center

Research Site
Sayre, PA United States
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Amgen Call Center

Research Site
Fort Worth, TX United States
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Amgen Call Center

Research Site
Galveston, TX United States
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Amgen Call Center

Research Site
Odessa, TX United States
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Amgen Call Center

Research Site
Salt Lake City, UT United States
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Amgen Call Center

Research Site
Charlottesville, VA United States
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Amgen Call Center

Research Site
Spokane, WA United States
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Amgen Call Center

Research Site
Milwaukee, WI United States
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Amgen Call Center

Research Site
Caba, Argentina
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Amgen Call Center

Research Site
San Miguel de Tucuman, Argentina
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Amgen Call Center

Research Site
Buenos Aires, Argentina
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Amgen Call Center

Research Site
Garran, Australia
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Amgen Call Center

Research Site
New Lambton Heights, Australia
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Amgen Call Center

Research Site
Herston, Australia
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Amgen Call Center

Research Site
Graz, Austria
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Amgen Call Center

Research Site
Linz, Austria
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Amgen Call Center

Research Site
Lodelinsart, Belgium
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Amgen Call Center

Research Site
Uberlandia, Brazil
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Amgen Call Center

Research Site
Londrina, Brazil
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Amgen Call Center

Research Site
Canoas, Brazil
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Amgen Call Center

Research Site
Marilia, Brazil
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Amgen Call Center

Research Site
Laval, QC Canada
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Amgen Call Center

Research Site
Osorno, Chile
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Amgen Call Center

Research Site
Guangzhou, China
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Amgen Call Center

Research Site
Xiangtan, China
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Amgen Call Center

Research Site
Suzhou, China
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Amgen Call Center

Research Site
Linhai, China
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Amgen Call Center

Research Site
Beijing, China
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Amgen Call Center

Research Site
Cali, Colombia
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Amgen Call Center

Research Site
Santiago de Cali, Colombia
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Amgen Call Center

Research Site
Kolin III, Czechia
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Amgen Call Center

Research Site
Praha 10, Czechia
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Amgen Call Center

Research Site
Zlin, Czechia
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Amgen Call Center

Research Site
Chambray les Tours, France
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Amgen Call Center

Research Site
Grenoble Cedex 9, France
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Amgen Call Center

Research Site
Le Chesnay, France
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Amgen Call Center

Research Site
Valenciennes, France
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Amgen Call Center

Research Site
Essen, Germany
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Amgen Call Center

Research Site
Frankfurt am Main, Germany
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Amgen Call Center

Research Site
Greifswald, Germany
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Amgen Call Center

Research Site
Leipzig, Germany
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Amgen Call Center

Research Site
Chaidari, Athens, Greece
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Amgen Call Center

Research Site
Sopron, Hungary
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Amgen Call Center

Research Site
Cuneo, Italy
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Amgen Call Center

Research Site
Foggia, Italy
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Amgen Call Center

Research Site
Piacenza, Italy
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Amgen Call Center

Research Site
Rozzano MI, Italy
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Amgen Call Center

Research Site
Seriate, Italy
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Amgen Call Center

Research Site
Nagakute-shi, Japan
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Amgen Call Center

Research Site
Urayasu-shi, Japan
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Amgen Call Center

Research Site
Imabari-shi, Japan
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Amgen Call Center

Research Site
Kasuya-gun, Japan
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Amgen Call Center

Research Site
Koga-shi, Japan
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Amgen Call Center

Research Site
Kurume-shi, Japan
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Amgen Call Center

Research Site
Hakodate-shi, Japan
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Amgen Call Center

Research Site
Sapporo-shi, Japan
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Amgen Call Center

Research Site
Kawanishi-shi, Japan
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Amgen Call Center

Research Site
Higashiibaraki-gun, Japan
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Amgen Call Center

Research Site
Morioka-shi, Japan
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Amgen Call Center

Research Site
Kawasaki-shi, Japan
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Amgen Call Center

Research Site
Odawara-shi, Japan
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Amgen Call Center

Research Site
Sagamihara-shi, Japan
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Amgen Call Center

Research Site
Nankoku-shi, Japan
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Amgen Call Center

Research Site
Kashihara-shi, Japan
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Amgen Call Center

Research Site
Okayama-shi, Japan
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Amgen Call Center

Research Site
Saga-shi, Japan
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Amgen Call Center

Research Site
Ageo-shi, Japan
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Amgen Call Center

Research Site
Sunto-gun, Japan
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Amgen Call Center

Research Site
Bunkyo-ku, Japan
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Amgen Call Center

Research Site
Hachioji-shi, Japan
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Amgen Call Center

Research Site
Minato-ku, Japan
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Amgen Call Center

Research Site
Mexico City, Mexico
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Amgen Call Center

Research Site
Pachuca, Mexico
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Amgen Call Center

Research Site
Guadalajara, Mexico
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Amgen Call Center

Research Site
San Luis Potosi, Mexico
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Amgen Call Center

Research Site
Culiacan, Mexico
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Amgen Call Center

Research Site
Xalapa, Mexico
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Amgen Call Center

Research Site
Arnhem, Netherlands
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Amgen Call Center

Research Site
Tilburg, Netherlands
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Amgen Call Center

Research Site
Zwolle, Netherlands
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Amgen Call Center

Research Site
Bialystok, Poland
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Amgen Call Center

Research Site
Bytom, Poland
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Amgen Call Center

Research Site
Kielce, Poland
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Amgen Call Center

Research Site
Klodzko, Poland
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Amgen Call Center

Research Site
Olawa, Poland
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Amgen Call Center

Research Site
Bucarest, Romania
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Amgen Call Center

Research Site
Oradea, Romania
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Amgen Call Center

Research Site
Targoviste, Romania
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Amgen Call Center

Research Site
Targu Mures, Romania
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Amgen Call Center

Research Site
Vladimir, Russian Federation
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Amgen Call Center

Research Site
Yaroslavl, Russian Federation
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Amgen Call Center

Research Site
Levice, Slovakia
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Amgen Call Center

Research Site
Nitra, Slovakia
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Amgen Call Center

Research Site
Presov, Slovakia
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