Last updated on February 2017

Effects of SRX246 on an Experimental Model of Fear and Anxiety in Humans


Brief description of study

To determine the effects of SRX246 on fear and anxiety based on fear-potentiated startle in humans. Additionally, the effects of the compound on emotion recognition will be explored.

Detailed Study Description

The study will use a double-blind, cross-over design in which each subject will receive placebo and SRX246 for 5-7 days before testing (given in counter-balanced order). The study will examine the effect of the drug on the potentiation of startle using a well-established paradigm that involves anticipation of no-shock, predictable shock, and unpredictable shock. Drug effects on emotion recognition will also be explored.

Clinical Study Identifier: NCT02922166

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Christian Grillon, PhD

National Institute of Mental Health
Bethesda, MD United States
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