Last updated on July 2018

A Study to Assess the Efficacy and Safety of MSTT1041A in Participants With Uncontrolled Severe Asthma


Brief description of study

This is a Phase IIb, randomized, placebo-controlled, double-blind, multicenter, multi-arm study will evaluate efficacy, safety, and pharmacokinetic of MSTT1041A compared with placebo as add-on therapy in participants with severe, uncontrolled asthma who are receiving mediumor high-dose inhaled corticosteroid (ICS) therapy and at least one of the following additional controller medications: long-acting beta-agonists (LABA), leukotriene modifier (LTM), long-acting muscarinic antagonist (LAMA), or long-acting theophylline preparation. The total duration of this study for each participant is approximately 70 weeks including screening, run-in, treatment, and follow-up.

Clinical Study Identifier: NCT02918019

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Reference Study ID Number: GB39242 ...

Alabama Allergy & Asthma
Birmingham, AL United States

Reference Study ID Number: GB39242 ...

Del Sol Research Management
Tucson, AZ United States

Reference Study ID Number: GB39242 ...

Kern Allergy Med Clinic, Inc.
Bakersfield, CA United States

Reference Study ID Number: GB39242 ...

Allianz Medical and Research Center
Fountain Valley, CA United States

Reference Study ID Number: GB39242 ...

Allergy & Asthma Care Center of Southern California
Long Beach, CA United States

Reference Study ID Number: GB39242 ...

CA Allergy & Asthma Med Grp; Medical Group, Inc.
Los Angeles, CA United States

Reference Study ID Number: GB39242 ...

Jonathan Corren MD, Inc.
Los Angeles, CA United States

Reference Study ID Number: GB39242 ...

Office of Robert N Wolfe MD
Los Angeles, CA United States

Reference Study ID Number: GB39242 ...

Advances in Medicine
Rancho Mirage, CA United States

Reference Study ID Number: GB39242 ...

Allergy & Asthma Consultants
Redwood City, CA United States

Reference Study ID Number: GB39242 ...

Bensch Research Associates
Stockton, CA United States

Reference Study ID Number: GB39242 ...

Allergy and Asthma Clinical Research, Inc.
Walnut Creek, CA United States

Reference Study ID Number: GB39242 ...

Asthma & Allergy; Associates, P.C.
Colorado Springs, CO United States

Reference Study ID Number: GB39242 ...

Colorado Allergy & Asthma Centers, Pc
Denver, CO United States

Reference Study ID Number: GB39242 ...

Western States Clinical Research, Inc
Wheat Ridge, CO United States

Reference Study ID Number: GB39242 ...

Yale University School Of Medicine
New Haven, CT United States

Reference Study ID Number: GB39242 ...

Research Institute of South Florida Inc
Miami, FL United States

Reference Study ID Number: GB39242 ...

Emerald Coast Research Associates
Panama City, FL United States

Reference Study ID Number: GB39242 ...

Florida Premier Research Institute
Winter Park, FL United States

Reference Study ID Number: GB39242 ...

Georgia Pollens Clinical Research Centers
Albany, GA United States

Reference Study ID Number: GB39242 ...

Atlanta Allergy & Asth Clin PC
Stockbridge, GA United States

Reference Study ID Number: GB39242 ...

Asthma & Allergy of Idaho
Twin Falls, ID United States

Reference Study ID Number: GB39242 ...

Asthma, Allergy & Sinus Center
Baltimore, MD United States

Reference Study ID Number: GB39242 ...

Chesapeake Clinical Research Inc - CRN
Baltimore, MD United States

Reference Study ID Number: GB39242 ...

Brigham & Women'S Hospital
Boston, MA United States

Reference Study ID Number: GB39242 ...

Genesis Clinical Research & Consulting, LLC
Fall River, MA United States

Reference Study ID Number: GB39242 ...

Infinity Medical Research Inc
North Dartmouth, MA United States

Reference Study ID Number: GB39242 ...

Midwest Clinical Research LLC
Saint Louis, MO United States

Reference Study ID Number: GB39242 ...

The Clinical Research Center LLC - CRN
Saint Louis, MO United States

Reference Study ID Number: GB39242 ...

The Allergy and Asthma Center
Bellevue, NE United States

Reference Study ID Number: GB39242 ...

Creighton University Medical Center
Omaha, NE United States

Reference Study ID Number: GB39242 ...

Atlantic Allergy Asthma Immunology Associates
Ocean City, NJ United States

Reference Study ID Number: GB39242 ...

Allergy Partners of Western NC
Asheville, NC United States

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Allergy & Respiratory Center
Canton, OH United States

Reference Study ID Number: GB39242 ...

Allied Clinical Research LLC
Springfield, OH United States

Reference Study ID Number: GB39242 ...

Integrity People Services Research Company
Oklahoma City, OK United States

Reference Study ID Number: GB39242 ...

Oklahoma Institute of Allergy and Asthma Clinical Research LLC
Oklahoma City, OK United States

Reference Study ID Number: GB39242 ...

Vital Prospects Clin Res Pc
Tulsa, OK United States

Reference Study ID Number: GB39242 ...

Clinical Research Inst. of Southern Oregon, Pc
Medford, OR United States

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Asthma Allergy Pulm Associates
Philadelphia, PA United States

Reference Study ID Number: GB39242 ...

Temple University Hospital
Philadelphia, PA United States

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Asthma & Allergy Physicians of Rhode Island Clinical Research Institute (AAPRI CRI)
Warwick, RI United States

Reference Study ID Number: GB39242 ...

Spartanburg Medical Research
Spartanburg, SC United States

Reference Study ID Number: GB39242 ...

Clinical Research Solutions PC
Knoxville, TN United States

Reference Study ID Number: GB39242 ...

Meharry Medical College; Clinical Trials Office
Nashville, TN United States

Reference Study ID Number: GB39242 ...

TTS Research
Boerne, TX United States

Reference Study ID Number: GB39242 ...

Elliot J. Ginchansky, MD, PA
Dallas, TX United States

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Western Sky Medical Research
El Paso, TX United States

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Baylor College of Medicine
Houston, TX United States

Reference Study ID Number: GB39242 ...

Pioneer Research Solutions
Houston, TX United States

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Allergy & Asthma Research Center
San Antonio, TX United States

Reference Study ID Number: GB39242 ...

Allergy Associates of Utah
Murray, UT United States

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Commonwealth Clinical Research Specialists
Richmond, VA United States

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Washington Univ School of Med
Seattle, WA United States

Reference Study ID Number: GB39242 ...

Premier Clinical Research
Spokane, WA United States

Reference Study ID Number: GB39242 ...

Instituto de Investigaciones Clinicas-Mar del Plata
Buenos Aires, Argentina

Reference Study ID Number: GB39242 ...

Fundacion Cidea
Buenos Aires, Argentina

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INSARES
Mendoza, Mendoza City, Argentina

Reference Study ID Number: GB39242 ...

Fundaci n Scherbovsky
Mendoza, Argentina

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Centro Respiratorio Quilmes
Quilmes, Argentina

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Centro Respiratorio Infantil
Rosario, Argentina

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Instituto de Diagn stico ABC; Servicio de Investigaci n de Patolog as Al rgicas
Rosario, Argentina

Reference Study ID Number: GB39242 ...

Instituto Especialidades de la Salud Rosario
Rosario, Argentina

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Centro Modelo de Cardiologia
San Miguel de Tucuman, Argentina

Reference Study ID Number: GB39242 ...

Investigaciones en Patologias Respiratorias
San Miguel de Tucuman, Argentina

Reference Study ID Number: GB39242 ...

Cliniques Universitaires St-Luc
Bruxelles, Belgium

Reference Study ID Number: GB39242 ...

Private Practice Dr Jean Benoit Martinot
Erpent, Belgium

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UZ Leuven Gasthuisberg
Leuven, Belgium

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Military Medical Academy HBAT
Pleven, Bulgaria

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SHATPPD Dr. Dimitar Gramatikov, Ruse Ltd.
Ruse, Bulgaria

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Medical Centre Mladost Med 1 EOOD
Sofia, Bulgaria

Reference Study ID Number: GB39242 ...

First MHAT; Clinic of Neurology
Sofia, Bulgaria

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Fifth MHAT - Sofia EAD
Sofia, Bulgaria

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National Multiprofile Hospital Tsar Boris III
Sofia, Bulgaria

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Specialised Hospital for Active Treatment of Pulmonary Deseases "Sv. Sofia", Third Clinic for Non-Sp
Sofia, Bulgaria

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Uni. Multiprofile Hosp. for Active Treatment-Aleksandrovska
Sofia, Bulgaria

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Medical Center N.I. Pirogov EOOD
Sofia, Bulgaria

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Alitera - Med - Medical Center EOOD
Sofia, Bulgaria

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Medical Center "Nov Rehabilitatsionen Tsentar", EOOD
Stara Zagora, Bulgaria

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Medical Center Tara OOD
Veliko Tarnovo, Bulgaria

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Aggarwal and Associates Lilmited
Brampton, ON Canada

Reference Study ID Number: GB39242 ...

Cheema Research, Inc
Mississauga, ON Canada

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Inspiration Research Limited
Toronto, ON Canada

Reference Study ID Number: GB39242 ...

Manna Research
Toronto, ON Canada

Reference Study ID Number: GB39242 ...

Dr Anil Dhar Professional Medicine Corporation
Windsor, ON Canada

Reference Study ID Number: GB39242 ...

MediTrial s.r.o.
Jindrichuv Hradec, Czechia

Reference Study ID Number: GB39242 ...

Fakultni nemocnice Olomouc
Olomouc, Czechia

Reference Study ID Number: GB39242 ...

MephaCentrum, a.s.
Ostrava - Poruba, Czechia

Reference Study ID Number: GB39242 ...

Ordinace pro tuberkulozu a respiracni nemoci
Strakonice, Czechia

Reference Study ID Number: GB39242 ...

KASMED s.r.o.
Tabor, Czechia

Reference Study ID Number: GB39242 ...

Alergologie Teplice, s.r.o.
Teplice, Czechia

Reference Study ID Number: GB39242 ...

Charit Research Organisation GmbH
Berlin, Germany

Reference Study ID Number: GB39242 ...

IKF Pneumologie
Frankfurt am Main, Germany

Reference Study ID Number: GB39242 ...

Medaimun GmbH
Frankfurt am Main, Germany

Reference Study ID Number: GB39242 ...

Pneumologisches Forschungsinstitut Hohegeest
Geesthacht, Germany

Reference Study ID Number: GB39242 ...

Hamburger Institut fur Therapieforschung GmbH
Hamburg, Germany

Reference Study ID Number: GB39242 ...

Praxis Dr. Axel Kroker
Koblenz, Germany

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POIS Leipzig Gbr
Leipzig, Germany

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Universit tsmedizin der Johannes Gutenberg-Universit t Mainz, Medizinische Klinik, Pneumologie
Mainz, Germany

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Ajou University Hospital
Gyeonggi-do, Korea, Republic of

Reference Study ID Number: GB39242 ...

Seoul National University Hospital
Seoul, Korea, Republic of

Reference Study ID Number: GB39242 ...

Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of

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Asan Medical Center
Seoul, Korea, Republic of

Reference Study ID Number: GB39242 ...

Korea University Guro Hospital
Seoul, Korea, Republic of

Reference Study ID Number: GB39242 ...

Optimal Clinical Trials
Auckland, New Zealand

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Greenlane Clinical Centre
Auckland, New Zealand

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Christchurch Hospital
Christchurch, New Zealand

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Waikato Hospital
Hamilton, New Zealand

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Medical Research Institute of New Zealand
Wellington, New Zealand

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Hospital Nacional Adolfo; Guevara Velasco Essalud
Cusco, Peru

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Clinica Internacional
Lima, Peru

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Abk Reuma Srl- Medicentro
Lima, Peru

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Clinica Ricardo Palma; THORAX
Lima, Peru

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Instituto Peruano de Investigacion en Ciencias Medicas
Lima, Peru

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Clinica San Borja
Lima, Peru

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Hospital Santa Rosa Piura
Piura, Peru

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Centrum Medycyny Oddechowej Robert M. Mr z
Bialystok, Poland

Reference Study ID Number: GB39242 ...

Malopolskie Centrum Alergologii
Krakow, Poland

Reference Study ID Number: GB39242 ...

SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi
Lodz, Poland

Reference Study ID Number: GB39242 ...

Specjalistyczna Poradnia Pulmonologiczna
Ostrow Wielkopolski, Poland

Reference Study ID Number: GB39242 ...

Przedsiebiorstwo Podmiotu Leczniczego Poradnie Specjalistyczne MAGMED
Radom, Poland

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ALERGO-MED Specjalistyczna Przychodnia Lekarska Sp. z o. o
Tarnow, Poland

Reference Study ID Number: GB39242 ...

Ewa Pisarczyk-Bogacka Specjalistyczna Praktyka Lekarska
Wroclaw, Poland

Reference Study ID Number: GB39242 ...

NZOZ Lekarze Specjali ci J. Ma olepszy i Partnerzy
Wroclaw, Poland

Reference Study ID Number: GB39242 ...

Theramed SRL
Brasov, Romania

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Spitalul Clinic de Pneumoftiziologie Leon Daniello Cluj-Napoca, Sectia Clinica Pneumologie I
Cluj-Napoca, Romania

Reference Study ID Number: GB39242 ...

Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Victor Babes Craiova
Craiova, Romania

Reference Study ID Number: GB39242 ...

Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital
Timisoara, Romania

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Clinical Emergency Hospital n.a.N.V. Soloviev
Yaroslavl, Russian Federation

Reference Study ID Number: GB39242 ...

LLC - ABC Medicina
Moscow, Russian Federation

Reference Study ID Number: GB39242 ...

City Hospital #5
Barnaul, Russian Federation

Reference Study ID Number: GB39242 ...

Municipal Healthcare Institution City Clinical Hospital #3 named after M.A. Podgorbunskogo
Kemerovo, Russian Federation

Reference Study ID Number: GB39242 ...

I.M. Sechenov Moscow State Medical University the Ministry of Health and Social Development of RF
Moscow, Russian Federation

Reference Study ID Number: GB39242 ...

Novosibirsk Municipal Clinical Hospital For Emergency Medicine #2
Novosibirsk, Russian Federation

Reference Study ID Number: GB39242 ...

City Clinical Hospital #2
Novosibirsk, Russian Federation

Reference Study ID Number: GB39242 ...

Ryazan State Medical University Named after I.P.Pavlov
Ryazan, Russian Federation

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Clinic Reavita LLC
St. Petersburg, Russian Federation

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SHI Ctr Occupational Pathology
St. Petersburg, Russian Federation

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St. Petersburg State Medical University n.a. I.P. Pavlov
St. Petersburg, Russian Federation

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City Hospital #40 of Resort Administrative District
St. Petersburg, Russian Federation

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Siberian State Medical University
Tomsk, Russian Federation

Reference Study ID Number: GB39242 ...

Tiervalei Trial Centre
Cape Town, South Africa

Reference Study ID Number: GB39242 ...

University of Cape Town Lung Institute; Lung Clinical Research
Cape Town, South Africa

Reference Study ID Number: GB39242 ...

St Augustines Hospital; Infectoilogy
Durban, South Africa

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Vawda Z.Fa Practice
Durban, South Africa

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Aliwal Shoal Medical Center
Umkomaas, South Africa

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Regional Municipal Institution Chernivtsi Regional Clinical Hospital
Chernivtsi, Ukraine

Reference Study ID Number: GB39242 ...

Municipal institution; City hospital #1; Department of Therapy
Zaporizhzhia, Ukraine

Reference Study ID Number: GB39242 ...

Kyiv City Tuberculosis Hospital #1; Department of Differential Diagnosis of Lung Diseases
Kyiv, Ukraine

Reference Study ID Number: GB39242 ...

Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board
Dnepropetrovsk, Ukraine

Reference Study ID Number: GB39242 ...

Ukrainian State Institute of Medical and Social Problems of Disability
Dnipropetrovsk, Ukraine

Reference Study ID Number: GB39242 ...

Regional Phthisiology and Pulmonology Center
Ivano-Frankivsk, Ukraine

Reference Study ID Number: GB39242 ...

SI Institute of Therapy n.a. L.T. Mala of National Academy of Medical Sciences of Ukraine
Kharkiv, Ukraine

Reference Study ID Number: GB39242 ...

SI National Institute of Phthisiology and Pulmonology n.a. F.G.Yanovskyi under NAMS of Ukraine
Kyiv, Ukraine

Reference Study ID Number: GB39242 ...

Municipal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital
Kyiv, Ukraine

Reference Study ID Number: GB39242 ...

Kyiv City Clinical Hospital #8
Kyiv, Ukraine

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City Hospital #1
Mykolaiv, Ukraine

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Municipal Institution Odesa Regional Clinical Hospital
Odesa, Ukraine

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Small Business Private Enterprise Medical Centre Pulse
Vinnytsya, Ukraine

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IMMUNOe Research Centers
Centennial, CO United States

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Montefiore Medical Center
Bronx, NY United States

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American Health Research Inc.
Charlotte, NC United States

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Clinical Research of Gastonia
Gastonia, NC United States

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Hickory Research Center
Hickory, NC United States

Reference Study ID Number: GB39242 ...

PMG Research of Wilmington
Wilmington, NC United States

Reference Study ID Number: GB39242 ...

Bernstein Clinical Research Center Llc
Cincinnati, OH United States

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Mainland Medical Research Institute
Dickinson, TX United States

Reference Study ID Number: GB39242 ...

Metroplex Pulmonology & Sleep Center
McKinney, TX United States

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South Texas Allergy and Asthma Medical Professionals
San Antonio, TX United States

Reference Study ID Number: GB39242 ...

Centrum Medyczne ALL-MED
Krakow, Poland

Reference Study ID Number: GB39242 ...

Fundatia CardioPrevent
Timisoara, Romania

Reference Study ID Number: GB39242 ...

INAER
Ciudad Autónoma de Buenos Aires, Argentina

Reference Study ID Number: GB39242 ...

CEMER Centro Medico de Enfermedades Respiratorias
Vicente López, Argentina

Reference Study ID Number: GB39242 ...

Centre d'investigation Clinique Mauricie
Trois-Rivières, QC Canada

Reference Study ID Number: GB39242 ...

Universit tsklinikum M nster
Münster, Germany

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Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.
Kraków, Poland