Last updated on October 2017

A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Participants With Metastatic or Unresectable Locally Advanced Melanoma


Brief description of study

This is a Phase III, double-blinded, placebo-controlled, randomized, multicenter study designed to evaluate the efficacy, safety, and pharmacokinetics of combination of atezolizumab (ATZ), cobimetinib and vemurafenib compared with combination of ATZ placebo, cobimetinib and vemurafenib in participants with previously untreated BRAFv600 mutation-positive metastatic or unresectable locally advanced melanoma.

Clinical Study Identifier: NCT02908672

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University of Alabama at Birmingham
Birmingham, AL United States
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HonorHealth Research Institute - Pima Center
Scottsdale, AZ United States
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Arizona Oncology Associates, PC - HAL
Tempe, AZ United States
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Highlands Oncology Group
Fayetteville, AR United States
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UC Irvine Medical Center
Orange, CA United States
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Ucsf Comprehensive Cancer Center; Medical Oncology
San Francisco, CA United States
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California Pacific Medical Center - Pacific Campus
San Francisco, CA United States
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Sutter Pacific Medical Foundation
Santa Rosa, CA United States
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Stanford Comprehensive Cancer Center
Stanford, CA United States
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Rocky Mountain Cancer Centers, LLP
Aurora, CO United States
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University of Colorado Cancer Center
Aurora, CO United States
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Florida Cancer Specialists; SCRI
Fort Myers, FL United States
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Mount Sinai Medical Center
Miami Beach, FL United States
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UF Health Cancer Center at Orlando Health
Orlando, FL United States
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Oncology Specialists, S.C.
Park Ridge, IL United States
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Indiana University Cancer Center
Indianapolis, IN United States
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Massachusetts General Hospital
Boston, MA United States
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Mayo Clinic
Rochester, MN United States
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Sarah Cannon Research Institute - Kansas City - HCA Midwest Health
Kansas City, MO United States
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MD Anderson Cancer Center at Cooper
Camden, NJ United States
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Hackensack U Med Ctr
Hackensack, NJ United States
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Morristown Medical Center
Morristown, NJ United States
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Overlook Hospital
Summit, NJ United States
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St. Luke's University Health network
Bethlehem, PA United States
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Thomas Jefferson University Hospital;Medical Oncology
Philadelphia, PA United States
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Tennessee Oncology; Sarah Cannon Cancer Center
Nashville, TN United States
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Texas Oncology-Austin Midtown
Austin, TX United States
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Texas Oncology-Tyler
Tyler, TX United States
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Orange Hospital
Orange, Australia
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Greenslopes Private Hospital
Greenslopes, Australia
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Townsville Hospital; Haematology and Oncology
Townsville, Australia
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Princess Alexandra Hospital
Woolloongabba, Australia
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Royal Adelaide Hospital
Adelaide, Australia
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Peter Maccallum Cancer Centre
Melbourne, Australia
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Fiona Stanley Hospital
Murdoch, Australia
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Medical University of Graz, Department of Dermatology
Graz, Austria
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LKH Innsbruck; Universit tsklinik f r Dermatologie
Innsbruck, Austria
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Medizinische Universit t Wien; Univ.Klinik f r Dermatologie
Wien, Austria
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Cliniques Universitaires St-Luc
Bruxelles, Belgium
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AZ Groeninge (Kennedylaan)
Kortrijk, Belgium
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UZ Leuven Gasthuisberg
Leuven, Belgium
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Sint Augustinus Wilrijk
Wilrijk, Belgium
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Clinicas Oncologicas Integradas - COI
Rio De Janeiro, Brazil
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Hospital das Clinicas - UFRGS
Porto Alegre, Brazil
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Centro de Pesquisas Oncologicas - CEPON
Florianopolis, Brazil
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Instituto do Cancer do Estado de Sao Paulo - ICESP
Sao Paulo, Brazil
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Hospital Sao Jose
São Paulo, Brazil
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Tom Baker Cancer Centre-Calgary
Calgary, AB Canada
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Bcca - Vancouver Island Cancer Centre; Oncology
Victoria, BC Canada
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Cancer Care Manitoba
Winnipeg, MB Canada
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Juravinski Cancer Clinic; Department of Oncology
Hamilton, ON Canada
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LHSC - Victoria Hospital; London Regional Cancer Program
London, ON Canada
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Lakeridge Health Oshawa; Oncology
Oshawa, ON Canada
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The Ottawa Hospital Cancer Centre; Oncology
Ottawa, ON Canada
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Princess Margaret Hospital
Toronto, ON Canada
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CHU de Qu bec
Quebec City, QC Canada
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Groupe Hospitalier Saint Andr - H pital Saint Andr
Bordeaux, France
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Hopital Ambroise Pare; Sce Dermatologie
Boulogne-billancourt, France
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Hopital du Bocage; Dermatologie
Dijon, France
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Centre Hospitalier Universitaire de Grenoble - Albert Michallon
La Tronche, France
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Hopital Claude Huriez - CHU Lille
Lille, France
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H pital de la Timone; Service de Dermatologie et Canc rologie Cutan e
Marseille, France
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Hopital Saint Eloi; CHU de Montpellier; Svc de Dermatologie
Montpellier, France
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CHU de Nantes; Canc ro-dermatologie
Nantes, France
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CHU Nice - Hopital de l'Archet 2
Nice, France
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Hopital Cochin; Dermatologie
Paris, France
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H pital Saint-Louis; Centre d'oncodermatologie
Paris, France
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Centre Hospitalier Lyon Sud; Dermatologie
Pierre Benite, France
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Hopital Robert Debre; DERMATOLOGIE
Reims, France
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Centre Eugene Marquis; Service d'oncologie
Rennes, France
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CHU de Rouen - H pital Charles Nicolle
Rouen, France
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Service d'Oncologie, Institut Universitaire du Cancer de Toulouse
Toulouse, France
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Institut Gustave Roussy; Dermatologie
Villejuif, France
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Charite - Universit tsmedizin Berlin
Berlin, Germany
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Elbekliniken Buxtehude; Klinik f r Dermatologie
Buxtehude, Germany
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HELIOS Klinikum Erfurt, Klinik f r Hautkrankheiten und Allergologie
Erfurt, Germany
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Universit tsklinikum Erlangen; Hautklinik
Erlangen, Germany
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Universitatsklinikum Essen; Klinik f r Dermatologie
Essen, Germany
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Universit tsmedizin G ttingen
Göttingen, Germany
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Medizinische Hochschule Hannover; Klinik f r Dermatologie, Allergologie und Venerologie
Hannover, Germany
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Universitatsklinik Heidelberg; Universit tshautklinik und Nationales Centrum f r Tumorerkrankungen
Heidelberg, Germany
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Reference Study ID Number: CO39262 ...

UKSH Kiel; Klinik f r Dermatologie, Venerologie und Allergologie
Kiel, Germany
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Klinikum d.Universit t zu K ln Klinik u.Poliklinik f.Dermatologie
Köln, Germany
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Universit tsklinikum Leipzig Klinik f.Dermatologie Venerologie u.Allergologie
Leipzig, Germany
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UKSH Universitatsklinikum Schleswig-Holstein; Studienzentrum Dermatologie 10d
Lübeck, Germany
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Klinik und Poliklinik fur Dermatologie; Universitatsklinikum Mainz
Mainz, Germany
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Reference Study ID Number: CO39262 ...

Klinikum der Ludwigs-Maximilians-Universit t M nchen; Dermatologie
München, Germany
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Reference Study ID Number: CO39262 ...

Fachklinik Hornheide; Dermatologie
Münster, Germany
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Klinikum N rnberg Nord; Hautklinik; Klinik f r Dermatologie
Nürnberg, Germany
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Harzklinikum Dorothea Christiane Erxleben GmbH, Standort Quedlinburg; Hautkrebszentrum Harz
Quedlinburg, Germany
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Universit tsklinikum Regensburg; Klinik und Poliklinik f r Dermatologie
Regensburg, Germany
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Zentrum f r Dermatoonkologie, Universit ts-Hautklinik T bingen
Tübingen, Germany
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Universit tsklinikum Wurzburg
Würzburg, Germany
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Laiko General Hospital Athen
Athens, Greece
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Metropolitan Hospital; Dept. of Oncology
Piraeus, Greece
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Orszagos Onkologiai Intezet; Borgyogyaszati Osztaly
Budapest, Hungary
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University of Szeged Szent-Gy rgyi Albert Clinical Center; Department of Dermatology and Allergology
Szeged, Hungary
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Rambam Health Care Campus; Oncology
Haifa, Israel
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Sharett Institute - Hadassah Hebrew University Medical Center
Jerusalem, Israel
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Rabin MC; Davidof Center - Oncology Institute
Petach Tikva, Israel
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Reference Study ID Number: CO39262 ...

Ella Institute - Sheba Medical Center
Ramat-Gan, Israel
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IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica B
Napoli, Italy
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IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, Italy
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Reference Study ID Number: CO39262 ...

A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia
Udine, Italy
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Reference Study ID Number: CO39262 ...

IFO - Istituto Regina Elena; Oncologia Medica
Roma, Italy
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IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A
Genova, Italy
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Reference Study ID Number: CO39262 ...

Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2
Milano, Italy
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Reference Study ID Number: CO39262 ...

Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica
Milano, Italy
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Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico
Candiolo, Italy
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Istituto Tumori "Giovanni Paolo II", Oncologia
Bari, Italy
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Reference Study ID Number: CO39262 ...

A.O.U. Senese Policlinico Santa Maria Alle Scotte
Siena, Italy
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Reference Study ID Number: CO39262 ...

Seoul National University Hospital
Seoul, Korea, Republic of
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Reference Study ID Number: CO39262 ...

Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of
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Asan Medical Center
Seoul, Korea, Republic of
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Samsung Medical Center
Seoul, Korea, Republic of
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Academ Ziekenhuis Groningen; Medical Oncology
Groningen, Netherlands
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Erasmus Mc - Daniel Den Hoed Kliniek; Interne Oncologie
Rotterdam, Netherlands
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Maxima Medisch Centrum; locatie Veldhoven
Veldhoven, Netherlands
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Auckland city hospital; Auckland Regional Cancer Centre and Blood Service
Auckland, New Zealand
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Wellington Hospital; Wellington Blood and Cancer Centre
Newtown, New Zealand
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Mid Central DHB
Palmerston North, New Zealand
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Tauranga Hospital, Clinical Trials Unit; BOP Clinical School
Tauranga, New Zealand
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Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii
Gdansk, Poland
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Szpital Uniwersytecki w Krakowie, Oddzia Kliniczny Kliniki Onkologii
Krakow, Poland
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Centrum Onkologii Instytut Klinika Nowotworow Ukladowych i Uogolnionych
Krakow, Poland
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COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej
Lublin, Poland
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