Last updated on April 2018

A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced Melanoma


Brief description of study

This is a Phase III, double-blinded, placebo-controlled, randomized, multicenter study designed to evaluate the efficacy, safety, and pharmacokinetics of atezolizumab + cobimetinib + vemurafenib compared with placebo + cobimetinib + vemurafenib in patients with previously untreated BRAFv600 mutation-positive metastatic or unresectable locally advanced melanoma.

Clinical Study Identifier: NCT02908672

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University of Alabama at Birmingham
Birmingham, AL United States
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HonorHealth Research Institute - Pima Center
Scottsdale, AZ United States
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Arizona Oncology Associates, PC - HAL
Tempe, AZ United States
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Highlands Oncology Group
Fayetteville, AR United States
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UC Irvine Medical Center
Orange, CA United States
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Ucsf Comprehensive Cancer Center; Medical Oncology
San Francisco, CA United States
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California Pacific Medical Center - Pacific Campus
San Francisco, CA United States
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Sutter Pacific Medical Foundation
Santa Rosa, CA United States
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Stanford Comprehensive Cancer Center
Stanford, CA United States
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University of Colorado Cancer Center
Aurora, CO United States
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Florida Cancer Specialists; SCRI
Fort Myers, FL United States
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Mount Sinai Medical Center
Miami Beach, FL United States
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UF Health Cancer Center at Orlando Health
Orlando, FL United States
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Oncology Specialists, S.C.
Park Ridge, IL United States
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Indiana University Cancer Center
Indianapolis, IN United States
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Massachusetts General Hospital
Boston, MA United States
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Mayo Clinic
Rochester, MN United States
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Sarah Cannon Research Institute - Kansas City - HCA Midwest Health
Kansas City, MO United States
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MD Anderson Cancer Center at Cooper
Camden, NJ United States
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Hackensack U Med Ctr
Hackensack, NJ United States
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Morristown Medical Center
Morristown, NJ United States
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Overlook Hospital
Summit, NJ United States
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St. Luke's University Health network
Bethlehem, PA United States
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Thomas Jefferson University Hospital;Medical Oncology
Philadelphia, PA United States
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Texas Oncology-Austin Midtown
Austin, TX United States
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Orange Hospital
Orange, Australia
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Greenslopes Private Hospital
Greenslopes, Australia
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Townsville Hospital; Haematology and Oncology
Townsville, Australia
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Princess Alexandra Hospital
Woolloongabba, Australia
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Royal Adelaide Hospital
Adelaide, Australia
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Peter Maccallum Cancer Centre
Melbourne, Australia
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Fiona Stanley Hospital
Murdoch, Australia
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Medical University of Graz, Department of Dermatology
Graz, Austria
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LKH Innsbruck; Universit tsklinik f r Dermatologie
Innsbruck, Austria
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Medizinische Universit t Wien; Univ.Klinik f r Dermatologie
Wien, Austria
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Cliniques Universitaires St-Luc
Bruxelles, Belgium
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UZ Leuven Gasthuisberg
Leuven, Belgium
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Sint Augustinus Wilrijk
Wilrijk, Belgium
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Clinicas Oncologicas Integradas - COI
Rio De Janeiro, Brazil
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Hospital das Clinicas - UFRGS
Porto Alegre, Brazil
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Centro de Pesquisas Oncologicas - CEPON
Florianopolis, Brazil
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Instituto do Cancer do Estado de Sao Paulo - ICESP
Sao Paulo, Brazil
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Tom Baker Cancer Centre-Calgary
Calgary, AB Canada
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Bcca - Vancouver Island Cancer Centre; Oncology
Victoria, BC Canada
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Cancer Care Manitoba
Winnipeg, MB Canada
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Juravinski Cancer Clinic; Department of Oncology
Hamilton, ON Canada
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LHSC - Victoria Hospital; London Regional Cancer Program
London, ON Canada
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Lakeridge Health Oshawa; Oncology
Oshawa, ON Canada
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The Ottawa Hospital Cancer Centre; Oncology
Ottawa, ON Canada
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Princess Margaret Hospital
Toronto, ON Canada
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CHU de Qu bec
Quebec City, QC Canada
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Groupe Hospitalier Saint Andr - H pital Saint Andr
Bordeaux, France
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Hopital Ambroise Pare; Sce Dermatologie
Boulogne-billancourt, France
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Hopital du Bocage; Dermatologie
Dijon, France
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Centre Hospitalier Universitaire de Grenoble - Albert Michallon
La Tronche, France
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Hopital Claude Huriez - CHU Lille
Lille, France
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H pital de la Timone; Service de Dermatologie et Canc rologie Cutan e
Marseille, France
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Hopital Saint Eloi; CHU de Montpellier; Svc de Dermatologie
Montpellier, France
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CHU de Nantes; Canc ro-dermatologie
Nantes, France
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CHU Nice - Hopital de l'Archet 2
Nice, France
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Hopital Cochin; Dermatologie
Paris, France
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H pital Saint-Louis; Centre d'oncodermatologie
Paris, France
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Centre Hospitalier Lyon Sud; Dermatologie
Pierre Benite, France
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Hopital Robert Debre; DERMATOLOGIE
Reims, France
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Centre Eugene Marquis; Service d'oncologie
Rennes, France
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CHU de Rouen - H pital Charles Nicolle
Rouen, France
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Service d'Oncologie, Institut Universitaire du Cancer de Toulouse
Toulouse, France
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Institut Gustave Roussy; Dermatologie
Villejuif, France
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Charite - Universit tsmedizin Berlin
Berlin, Germany
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Elbekliniken Buxtehude; Klinik f r Dermatologie
Buxtehude, Germany
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HELIOS Klinikum Erfurt, Klinik f r Hautkrankheiten und Allergologie
Erfurt, Germany
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Universit tsklinikum Erlangen; Hautklinik
Erlangen, Germany
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Universitatsklinikum Essen; Klinik f r Dermatologie
Essen, Germany
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Medizinische Hochschule Hannover; Klinik f r Dermatologie, Allergologie und Venerologie
Hannover, Germany
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Universitatsklinik Heidelberg; Universit tshautklinik und Nationales Centrum f r Tumorerkrankungen
Heidelberg, Germany
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UKSH Kiel; Klinik f r Dermatologie, Venerologie und Allergologie
Kiel, Germany
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Klinik und Poliklinik fur Dermatologie; Universitatsklinikum Mainz
Mainz, Germany
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Harzklinikum Dorothea Christiane Erxleben GmbH, Standort Quedlinburg; Hautkrebszentrum Harz
Quedlinburg, Germany
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Universit tsklinikum Regensburg; Klinik und Poliklinik f r Dermatologie
Regensburg, Germany
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Laiko General Hospital Athen
Athens, Greece
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Metropolitan Hospital; Dept. of Oncology
Piraeus, Greece
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Orszagos Onkologiai Intezet; Borgyogyaszati Osztaly
Budapest, Hungary
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University of Szeged Szent-Gy rgyi Albert Clinical Center; Department of Dermatology and Allergology
Szeged, Hungary
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Rambam Health Care Campus; Oncology
Haifa, Israel
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Sharett Institute - Hadassah Hebrew University Medical Center
Jerusalem, Israel
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Rabin MC; Davidof Center - Oncology Institute
Petach Tikva, Israel
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Ella Institute - Sheba Medical Center
Ramat-Gan, Israel
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IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica B
Napoli, Italy
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IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
Meldola, Italy
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A.O. Universitaria S. Maria Della Misericordia Di Udine; Oncologia
Udine, Italy
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IFO - Istituto Regina Elena; Oncologia Medica
Roma, Italy
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IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A
Genova, Italy
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Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2
Milano, Italy
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Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica
Milano, Italy
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Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico
Candiolo, Italy
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Istituto Tumori "Giovanni Paolo II", Oncologia
Bari, Italy
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A.O.U. Senese Policlinico Santa Maria Alle Scotte
Siena, Italy
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Seoul National University Hospital
Seoul, Korea, Republic of
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Severance Hospital, Yonsei University Health System
Seoul, Korea, Republic of
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Asan Medical Center
Seoul, Korea, Republic of
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Samsung Medical Center
Seoul, Korea, Republic of
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Academ Ziekenhuis Groningen; Medical Oncology
Groningen, Netherlands
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Erasmus Mc - Daniel Den Hoed Kliniek; Interne Oncologie
Rotterdam, Netherlands
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Maxima Medisch Centrum; locatie Veldhoven
Veldhoven, Netherlands
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Auckland city hospital; Auckland Regional Cancer Centre and Blood Service
Auckland, New Zealand
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Wellington Hospital; Wellington Blood and Cancer Centre
Newtown, New Zealand
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Mid Central DHB
Palmerston North, New Zealand
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Tauranga Hospital, Clinical Trials Unit; BOP Clinical School
Tauranga, New Zealand
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Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii
Gdansk, Poland
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Szpital Uniwersytecki w Krakowie, Oddzia Kliniczny Kliniki Onkologii
Krakow, Poland
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Centrum Onkologii Instytut Klinika Nowotworow Ukladowych i Uogolnionych
Krakow, Poland
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COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej
Lublin, Poland
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Sarah Cannon Research Institute
Nashville, TN United States
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Rocky Mountain Cancer Centers, LLP
Irving, TX United States
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Texas Oncology-Tyler
Irving, TX United States
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Universit tsklinikum Leipzig; Klinik f r Dermatologie, Venerologie und Allergologie
Leipzig, Germany
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Hospital Sao Jose
São Paulo, Brazil
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Universit tsmedizin G ttingen
Göttingen, Germany
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Klinikum d.Universit t zu K ln Klinik u.Poliklinik f.Dermatologie
Köln, Germany
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UKSH Universitatsklinikum Schleswig-Holstein; Studienzentrum Dermatologie 10d
Lübeck, Germany
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Klinikum der Ludwigs-Maximilians-Universit t M nchen; Dermatologie
München, Germany
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Fachklinik Hornheide; Dermatologie
Münster, Germany
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Klinikum N rnberg Nord; Hautklinik; Klinik f r Dermatologie
Nürnberg, Germany
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Zentrum f r Dermatoonkologie, Universit ts-Hautklinik T bingen
Tübingen, Germany
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Universit tsklinikum Wurzburg
Würzburg, Germany
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