Last updated on July 2017

The Circulating Cell-free Genome Atlas Study


Brief description of study

GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer.

Detailed Study Description

This is a prospective, multi-center, observational study with collection of de-identified biospecimens and clinical data from at least 10,000 participants from clinical networks in the United States. The study will enroll at least 7000 cancer subjects with multiple solid tumor types (the CANCER arm) and at least 3000 representative subjects without a clinical diagnosis of cancer (the NON-CANCER arm). Cancer subjects with a new diagnosis and no prior systemic therapy will be recruited. Clinical data relevant to cancer status are collected from all participants and their medical record at baseline, and subsequently from the medical record at intermittent future time points, at least annually for up to 5 years. The study test(s) to be used in this protocol are next generation sequencing (NGS)-based assay(s) that are under investigation and development at GRAIL.

Clinical Study Identifier: NCT02889978

.

Contact Investigators or Research Sites near you

Start Over

Please choose location

View all locations

Michael Meshad, MD

Southern Cancer Center, PC - Daphne
Daphne, AL United States
  Connect »

Michael Meshad, MD

Southern Cancer Center, P.C. - Mobile Infimary
Mobile, AL United States
  Connect »

Michael Meshad, MD

Southern Cancer Center, PC - Springhill Medical Center
Mobile, AL United States
  Connect »

Alan Bryce, MD

Mayo Clinic - Arizona
Scottsdale, AZ United States
  Connect »

Mohan Tummala, MD

Mercy Fort Smith
Fort Smith, AR United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Centers
Aurora, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Center
Boulder, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Center
Colorado Springs, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Centers
Denver, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Center
Lakewood, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Centers
Littleton, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Centers
Lone Tree, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Centers
Longmont, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Centers
Parker, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Center
Pueblo, CO United States
  Connect »

Allen L Cohn, MD

Rocky Mountain Cancer Centers
Thornton, CO United States
  Connect »

Peter Yu, MD

Hartford HealthCare Cancer Institute at Hartford Hospital
Hartford, CT United States
  Connect »

Johnathan C Trent, MD

University of Miami Sylvester at Deerfield Beach
Deerfield Beach, FL United States
  Connect »

Johnathan C Trent, MD

University of Miami Sylvester at Hollywood
Hollywood, FL United States
  Connect »

Alex Parker, MD

Mayo Clinic - Florida
Jacksonville, FL United States
  Connect »

Johnathan C Trent, MD

University of Miami Sylvester at Kendall
Kendall, FL United States
  Connect »

Johnathan C Trent, MD

University of Miami Sylvester Comprehensive Cancer Center
Miami, FL United States
  Connect »

Johnathan C Trent, MD

University of Miami Sylvester at Plantation
Plantation, FL United States
  Connect »

Richard S Siegel, MD

Illinois Cancer Specialists
Arlington Heights, IL United States
  Connect »

Richard S Siegel, MD

Illinois Cancer Specialists
Niles, IL United States
  Connect »

Daron Davis, MD

Baptist Health Lexington
Lexington, KY United States
  Connect »

Daron Davis, MD

Baptist Health Louisville
Louisville, KY United States
  Connect »

Daron Davis, MD

Baptist Health Paducah
Paducah, KY United States
  Connect »

Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Bethesda, MD United States
  Connect »

Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Clinton, MD United States
  Connect »

Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Columbia, MD United States
  Connect »

Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Rockville, MD United States
  Connect »

Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Silver Spring, MD United States
  Connect »

Kim Christ, PhD

Lahey Hospital & Medical Center
Burlington, MA United States
  Connect »

Timothy G Larson, MD

Minnesota Oncology Hematology, P.A.
Coon Rapids, MN United States
  Connect »

Timothy G Larson, MD

Minnesota Oncology Hematology, P.A.
Edina, MN United States
  Connect »

Timothy G Larson, MD

Minnesota Oncology Hematology, P.A.
Minneapolis, MN United States
  Connect »

Minetta Liu, MD

Mayo Clinic - Minnesota
Rochester, MN United States
  Connect »

Timothy G Larson, MD

Minnesota Oncology Hematology, P.A.
Woodbury, MN United States
  Connect »

Mohan Tummala, MD

Mercy Joplin
Joplin, MO United States
  Connect »

Mohan Tummala, MD

Mercy Research - Springfield
Springfield, MO United States
  Connect »

Lawrence E Garbo, MD

New York Oncology Hematology, P.C.
Albany, NY United States
  Connect »

Ronald P Harris, MD

Broome Oncology, LLC
Binghamton, NY United States
  Connect »

Lawrence E Garbo, MD

New York Oncology Hematology, P.C.
Clifton Park, NY United States
  Connect »

Ronald P Harris, MD

Broome Oncology, LLC
Johnson City, NY United States
  Connect »

Nadeem Abu-Rustum

Memorial Sloan Kettering
New York, NY United States
  Connect »

David M Waterhouse, MD

Oncology Hematology Care, Inc.
Cincinnati, OH United States
  Connect »

Philip Leming, MD

Christ Hospital Health Network - The Lindner Center Cancer Research Division
Cincinnati, OH United States
  Connect »

Eric Klein, MD

Cleveland Clinic
Cleveland, OH United States
  Connect »

David M Waterhouse, MD

Oncology Hematology Care, Inc.
Fairfield, OH United States
  Connect »

David A Smith, MD

Northwest Cancer Specialists, P.C. dba Compass Oncology
Portland, OR United States
  Connect »

David A Smith, MD

Northwest Cancer Specialists, P.C. dba Compass Oncology
Tualatin, OR United States
  Connect »

Robert Siegel, MD

Bon Secours Saint Francis Cancer Center
Greenville, SC United States
  Connect »

Jeffrey K Giguere, MD

Greenville Health System
Seneca, SC United States
  Connect »

Rosanna Lapham, MD

Spartanburg Regional Healthcare System
Spartanburg, SC United States
  Connect »

Amy Krie, MD

Avera Research Institute
Sioux Falls, SD United States
  Connect »

Leonardo Forero, MD

Texas Oncology - Amarillo Cancer Center
Amarillo, TX United States
  Connect »

Thomas C Anderson, MD

Texas Oncology-Bedford
Bedford, TX United States
  Connect »

Kristi J McIntyre, MD

Texas Oncology - Presbyterian Cancer Center Dallas
Dallas, TX United States
  Connect »

Carlos H Roberto Becerra, MD

Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, TX United States
  Connect »

Jennifer Snow, MD

Texas Oncology-Fort Worth
Fort Worth, TX United States
  Connect »

Jennifer Snow, MD

Texas Oncology-Southwest Fort Worth
Fort Worth, TX United States
  Connect »

Alvaro Restrepo, MD

Texas Oncology Cancer Care and Research Center - Harlingen
Harlingen, TX United States
  Connect »

Donald A Richards, MD

Texas Oncology - Longview Cancer Center
Longview, TX United States
  Connect »

Alvaro Restrepo, MD

Texas Oncology - McAllen
McAllen, TX United States
  Connect »

Sridhar Beeram, MD

Texas Oncology-New Braunfels
New Braunfels, TX United States
  Connect »

Sharon Wilks, MD

Texas Oncology-San Antonio Downtown
San Antonio, TX United States
  Connect »

Sharon T Wilks, MD

Texas Oncology - San Antonio Northeast
San Antonio, TX United States
  Connect »

Sridhar Beeram, MD

Texas Oncology-San Antonio Medical Center
San Antonio, TX United States
  Connect »

Sharon Wilks, MD

Texas Oncology-San Antonio Stone Oak
San Antonio, TX United States
  Connect »

Donald A Richards, MD

Texas Oncology - Tyler
Tyler, TX United States
  Connect »

Alvaro Restrepo, MD

Texas Oncology - Weslaco
Weslaco, TX United States
  Connect »

Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Alexandria, VA United States
  Connect »

Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Arlington, VA United States
  Connect »

Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Fairfax, VA United States
  Connect »

Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Gainesville, VA United States
  Connect »

Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Leesburg, VA United States
  Connect »

Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Woodbridge, VA United States
  Connect »

David A Smith, MD

Northwest Cancer Specialists, P.C. dba Compass Oncology
Vancouver, WA United States
  Connect »

Vicky E Jones, MD

Yakima Valley Memorial Hospital/North Star Lodge
Yakima, WA United States
  Connect »