Last updated on May 2018

The Circulating Cell-free Genome Atlas Study


Brief description of study

GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer.

Detailed Study Description

This is a prospective, multi-center, observational study with collection of de-identified biospecimens and clinical data from at least 15,000 participants from clinical networks in the United States and Canada. The study will enroll approximately 10,500 cancer subjects with multiple types of malignancies (CANCER arm) and approximately 4,500 representative subjects without a clinical diagnosis of cancer (NON-CANCER arm). Clinical information, demographics, and medical data relevant to cancer status are collected from all participants and their medical record at baseline (time of biospecimen collection), and subsequently from the medical record at intermittent future time points, at least annually for up to 5 years. The study test(s) to be used in this protocol are next generation sequencing (NGS)-based assay(s) that are under investigation and development at GRAIL.

Clinical Study Identifier: NCT02889978

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Michael Meshad, MD

Southern Cancer Center, PC - Daphne
Daphne, AL United States
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Michael Meshad, MD

Southern Cancer Center, P.C. - Mobile Infimary
Mobile, AL United States
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Michael Meshad, MD

Southern Cancer Center, PC - Springhill Medical Center
Mobile, AL United States
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Alan Bryce, MD

Mayo Clinic - Arizona
Scottsdale, AZ United States
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Mohan Tummala, MD

Mercy Fort Smith
Fort Smith, AR United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Aurora, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Center
Boulder, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Center
Colorado Springs, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Denver, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Center
Lakewood, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Littleton, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Lone Tree, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Longmont, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Parker, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Center
Pueblo, CO United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Thornton, CO United States
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Peter Yu, MD

Hartford HealthCare Cancer Institute at Hartford Hospital
Hartford, CT United States
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Johnathan C Trent, MD

University of Miami Sylvester at Deerfield Beach
Deerfield Beach, FL United States
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Johnathan C Trent, MD

University of Miami Sylvester at Hollywood
Hollywood, FL United States
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Alex Parker, MD

Mayo Clinic - Florida
Jacksonville, FL United States
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Johnathan C Trent, MD

University of Miami Sylvester at Kendall
Kendall, FL United States
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Johnathan C Trent, MD

University of Miami Sylvester Comprehensive Cancer Center
Miami, FL United States
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Johnathan C Trent, MD

University of Miami Sylvester at Plantation
Plantation, FL United States
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Richard S Siegel, MD

Illinois Cancer Specialists
Arlington Heights, IL United States
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Richard S Siegel, MD

Illinois Cancer Specialists
Niles, IL United States
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Daron Davis, MD

Baptist Health Lexington
Lexington, KY United States
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Daron Davis, MD

Baptist Health Louisville
Louisville, KY United States
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Daron Davis, MD

Baptist Health Paducah
Paducah, KY United States
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Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Bethesda, MD United States
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Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Clinton, MD United States
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Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Columbia, MD United States
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Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Rockville, MD United States
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Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Silver Spring, MD United States
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Kim Christ, PhD

Lahey Hospital & Medical Center
Burlington, MA United States
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Mohan Tummala, MD

Mercy Joplin
Joplin, MO United States
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Mohan Tummala, MD

Mercy Research - Springfield
Springfield, MO United States
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Lawrence E Garbo, MD

New York Oncology Hematology, P.C.
Albany, NY United States
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Ronald P Harris, MD

Broome Oncology, LLC
Binghamton, NY United States
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Lawrence E Garbo, MD

New York Oncology Hematology, P.C.
Clifton Park, NY United States
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Ronald P Harris, MD

Broome Oncology, LLC
Johnson City, NY United States
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Nadeem Abu-Rustum

Memorial Sloan Kettering
New York, NY United States
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Philip Leming, MD

Christ Hospital Health Network - The Lindner Center Cancer Research Division
Cincinnati, OH United States
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Eric Klein, MD

Cleveland Clinic
Cleveland, OH United States
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David A Smith, MD

Northwest Cancer Specialists, P.C. dba Compass Oncology
Portland, OR United States
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David A Smith, MD

Northwest Cancer Specialists, P.C. dba Compass Oncology
Tualatin, OR United States
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Robert Siegel, MD

Bon Secours Saint Francis Cancer Center
Greenville, SC United States
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Jeffrey K Giguere, MD

Greenville Health System
Seneca, SC United States
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Rosanna Lapham, MD

Spartanburg Regional Healthcare System
Spartanburg, SC United States
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Amy Krie, MD

Avera Research Institute
Sioux Falls, SD United States
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Leonardo Forero, MD

Texas Oncology - Amarillo Cancer Center
Amarillo, TX United States
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Thomas C Anderson, MD

Texas Oncology-Bedford
Bedford, TX United States
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Kristi J McIntyre, MD

Texas Oncology - Presbyterian Cancer Center Dallas
Dallas, TX United States
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Carlos H Roberto Becerra, MD

Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, TX United States
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Jennifer Snow, MD

Texas Oncology-Fort Worth
Fort Worth, TX United States
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Jennifer Snow, MD

Texas Oncology-Southwest Fort Worth
Fort Worth, TX United States
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Alvaro Restrepo, MD

Texas Oncology Cancer Care and Research Center - Harlingen
Harlingen, TX United States
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Donald A Richards, MD

Texas Oncology - Longview Cancer Center
Longview, TX United States
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Alvaro Restrepo, MD

Texas Oncology - McAllen
McAllen, TX United States
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Sridhar Beeram, MD

Texas Oncology-New Braunfels
New Braunfels, TX United States
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Sharon Wilks, MD

Texas Oncology-San Antonio Downtown
San Antonio, TX United States
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Sharon T Wilks, MD

Texas Oncology - San Antonio Northeast
San Antonio, TX United States
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Sridhar Beeram, MD

Texas Oncology-San Antonio Medical Center
San Antonio, TX United States
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Sharon Wilks, MD

Texas Oncology-San Antonio Stone Oak
San Antonio, TX United States
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Donald A Richards, MD

Texas Oncology - Tyler
Tyler, TX United States
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Alvaro Restrepo, MD

Texas Oncology - Weslaco
Weslaco, TX United States
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Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Alexandria, VA United States
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Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Arlington, VA United States
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Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Fairfax, VA United States
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Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Gainesville, VA United States
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Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Leesburg, VA United States
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Timothy A McCarthy, MD

Virginia Cancer Specialists, PC
Woodbridge, VA United States
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David A Smith, MD

Northwest Cancer Specialists, P.C. dba Compass Oncology
Vancouver, WA United States
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Vicky E Jones, MD

Yakima Valley Memorial Hospital/North Star Lodge
Yakima, WA United States
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Michael Meshad, MD

Southern Cancer Center, PC - Mobile Airport
Mobile, AL United States
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Daniel Greenwald, MD

Sansum Clinic - 540
Santa Barbara, CA United States
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Kate Kurtzman, MD

Sansum Clinic- 317
Santa Barbara, CA United States
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Daniel Greenwald, MD

Sansum Clinic - Viborg
Solvang, CA United States
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Allen L Cohn, MD

Rocky Mountain Cancer Centers
Englewood, CO United States
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Peter Yu, MD

Hartford New Britain
New Britain, CT United States
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Johnathan C Trent, MD

UMHC Lennar Foundation - Coral Gables
Coral Gables, FL United States
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Johnathan C Trent, MD

UMHC Sylvester- Coral Springs
Coral Springs, FL United States
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Rama Balaraman, MD

Florida Cancer Affiliates - Ocala
Ocala, FL United States
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Rami Owera, MD

Woodlands Medical Specialists, PA
Pensacola, FL United States
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Manish Agrawal, MD

Maryland Oncology Hematology, P.A.
Brandywine, MD United States
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Kim Christ, PhD

Lahey Hospital & Medical Center - Peabody
Peabody, MA United States
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Timothy G Larson, MD

Minnesota Oncology Hematology, P.A. - Main
Coon Rapids, MN United States
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Timothy G Larson, MD

Minnesota Oncology Hematology, P.A. - Edina
Edina, MN United States
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Timothy G Larson, MD

Minnesota Oncology Hematology, P.A. - Woodbury
Minneapolis, MN United States
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Minetta Liu, MD

Mayo Clinic - Rochester
Rochester, MN United States
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Timothy G Larson, MD

Minnesota Oncology Hematology, P.A. - Coon Rapids
Woodbury, MN United States
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Nadeem Abu-Rustum, MD

Memorial Sloan Kettering, NY - Monmouth
Middletown, NJ United States
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William Oh, MD

Icahn School of Medicine at Mount Sinai
New York, NY United States
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Nadeem Abu-Rustum, MD

Memorial Sloan Kettering - Basking Ridge
New York, NY United States
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Nadeem Abu-Rustum, MD

Memorial Sloan Kettering - Rockville Center
New York, NY United States
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Nadeem Abu-Rustum, MD

Memorial Sloan Kettering, NY - Commack
New York, NY United States
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Nadeem Abu-Rustum, MD

Memorial Sloan Kettering, NY - West Harrison
New York, NY United States
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David M Waterhouse, MD

Oncology Hematology Care, Inc. - Reading Road
Cincinnati, OH United States
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David M Waterhouse, MD

Oncology Hematology Care, Inc. - Fairfield
Cincinnati, OH United States
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David M Waterhouse, MD

Oncology Hematology Care, Inc. - Mercy Health
Cincinnati, OH United States
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David M Waterhouse, MD

Oncology Hematology Care, Inc. - E. Galbraith
Cincinnati, OH United States
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David M Waterhouse, MD

Oncology Hematology Care, Inc. - Malsbary
Cincinnati, OH United States
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David M Waterhouse, MD

Oncology Hematology Care, Inc. - Five Mile Road
Fairfield, OH United States
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Christopher Corless, MD

Oregon Health & Science University Knight Cancer Institute
Portland, OR United States
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Maged Khalil, MD

Lehigh Valley Hospital - Cedar Crest
Allentown, PA United States
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Maged Khalil, MD

Cancer Center at Lehigh Valley Hospital - Muhlenberg
Bethlehem, PA United States
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David Spigel, MD

Tennessee Oncology Medical Park II
Chattanooga, TN United States
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David Spigel, MD

Tennessee Oncology Memorial Plaza
Chattanooga, TN United States
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David Spigel, MD

Tennessee Oncology Cleveland Clinic
Cleveland, TN United States
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David Spigel, MD

Tennessee Oncology CMC
Crossville, TN United States
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David Spigel, MD

Tennessee Oncology Dickson
Dickson, TN United States
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David Spigel, MD

Tennessee Oncology Franklin
Franklin, TN United States
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David Spigel, MD

Tennessee Oncology Gallatin
Gallatin, TN United States
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David Spigel, MD

Tennessee Oncology Summit
Hermitage, TN United States
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David Spigel, MD

Tennessee Oncology Lebanon
Lebanon, TN United States
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David Spigel, MD

Tennessee Oncology Murfreesboro
Murfreesboro, TN United States
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David Spigel, MD

Tennessee Oncology Midtown
Nashville, TN United States
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David Spigel, MD

Tennessee Oncology Nashville
Nashville, TN United States
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David Spigel, MD

Tennessee Oncology SCCBC
Nashville, TN United States
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David Spigel, MD

Tennessee Oncology St. Thomas West
Nashville, TN United States
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David Spigel, MD

Tennessee Oncology Skyline
Nashville, TN United States
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David Spigel, MD

Tennessee Oncology Southern Hills
Nashville, TN United States
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David Spigel, MD

Tennessee Oncology Shelbyville
Shelbyville, TN United States
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David Spigel, MD

Tennessee Oncology Stonecrest
Smyrna, TN United States
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Atisha P Manhas, MD

TXO - Methodist Dallas Cancer Center
Dallas, TX United States
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Jay G Courtright, MD

Texas Oncology - Dallas Forest Ln
Dallas, TX United States
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Thomas C Anderson, MD

Texas Oncology - Grapevine
Grapevine, TX United States
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Shiela Haffar, MD

Texas Oncology - Mesquite
Mesquite, TX United States
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Christopher T Stokoe, MD

Texas Oncology - Plano East
Plano, TX United States
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Philip Kovoor, MD

Texas Oncology - Plano West
Plano, TX United States
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Shiela Haffar, MD

Texas Oncology - Rockwall
Rockwall, TX United States
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Tammy E Roque, MD

Texas Oncology - Sherman
Sherman, TX United States
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Christine M Lee, MD

Texas Oncology-The Woodlands
The Woodlands, TX United States
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Brian K Ulrich, MD

Texas Oncology - Wichita Falls
Wichita Falls, TX United States
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Hagen Kennecke, MD

Benaroya Research Institute at Virginia Mason
Seattle, WA United States
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Neil Fleshner, MD

UHN Princess Margaret Cancer Centre
Toronto, ON Canada
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Geoffrey R Oxnard, MD

Dana-Farber Cancer Institute
Boston, MA United States
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